Suicidality and Antidepressant Drugs
Antidepressants increased the risk of suicidal thinking and behavior in children, teens, and young adults. Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients of all ages who are started on antidepressant therapy or when the dose is changed should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior such as becoming agitated, irritable, hostile, aggressive, impulsive, or restless. Should these occur, report them to a doctor right away. PRISTIQ is not approved for use in children under 18.

Do not take PRISTIQ if you are allergic to desvenlafaxine, venlafaxine, or any of the ingredients in PRISTIQ. Do not take PRISTIQ if you currently take, or have taken within the last 14 days, any medicine known as an MAOI (including intravenous methylene blue or the antibiotic linezolid). Allow 7 days after stopping PRISTIQ before starting an MAOI. Taking an MAOI with PRISTIQ can cause serious or even life-threatening side effects.

Before taking PRISTIQ, tell your healthcare professional about all prescription and over-the-counter medications and supplements you take or plan to take including: those to treat migraines or psychiatric disorders (including other antidepressants) to avoid serotonin syndrome, a potentially life-threatening condition; aspirin, NSAID pain relievers, or blood thinners because they may increase the risk of bleeding.

PRISTIQ may cause or worsen some conditions, so tell your healthcare professional about all the medical conditions you have or had including:

• High blood pressure, which should be controlled before starting PRISTIQ and monitored regularly
• Heart problems, high cholesterol or triglyceride levels, a history of stroke, kidney or liver problems, or low sodium levels in your blood
• Bleeding problems
• Depression, suicidal thoughts or behavior
• Mania, bipolar disorder, or seizures or convulsions
• Nursing, pregnancy, or plans to become pregnant

Some people are at risk for visual problems such as eye pain, changes in vision, or swelling or redness around the eye. You may want to undergo an eye examination to see if you are at risk and get preventative treatment if you are.

Discontinuation symptoms may occur when stopping or reducing PRISTIQ, so talk to your healthcare professional before stopping or changing your dose.

Until you see how PRISTIQ affects you, be careful driving a car or operating machinery. Avoid drinking alcohol while taking PRISTIQ.

In clinical studies, most common side effects with PRISTIQ 50 mg were nausea, dizziness, sweating, constipation, and decreased appetite.

INDICATION
PRISTIQ (desvenlafaxine) is a prescription medication approved for the treatment of major depressive disorder in adults.

*Terms and Conditions
By using the PRISTIQ Savings Card, you acknowledge that you currently meet the eligibility criteria and will comply with the terms and conditions described below:

• The Card is not valid for prescriptions that are eligible to be reimbursed, in whole or in part, by Medicaid, Medicare, or other federal or state health care programs including any state prescription drug assistance programs and the Government Health Insurance Plan available in Puerto Rico (formerly known as “La Reforma de Salud”).
• The Card is not valid for prescriptions that are eligible to be reimbursed by private insurance plans or other health or pharmacy benefit programs which reimburse you for the entire cost of your prescription drugs.
• You will save either $15 or the amount of your co-pay/out-of-pocket cost, whichever is less. Card can only be used for up to 12 prescriptions per year.
• You must deduct the value received under this program from any reimbursement request submitted to your insurance plan, either directly by you or on your behalf.
• Cannot be combined with any other rebate/coupon, free trial, or similar offer for the specified prescription.
• The Card will be accepted only at participating pharmacies.
• This Card is not health insurance.
• Offer good only in the U.S. and Puerto Rico.
• The Card is limited to one person during this offering period and is not transferable.
• Pfizer reserves the right to rescind, revoke, or amend the program without notice.
• No membership fees.
• Card and program expire 12/31/15.
• If your pharmacy does not accept this savings card or if you use a mail-order service:
• Pay for your PRISTIQ prescription as you normally would
• Send a copy of the original pharmacy receipt (cash-register receipt not valid) with product name, date, and amount you paid circled. Include it with a copy of the front of your PRISTIQ Savings Card, and mail it with your name and address information to:
PRISTIQ Savings Card 14001 Weston Parkway, Suite 103, Cary, NC 27513-9967
• A check will be mailed to you within 3 weeks
Program expiration dates are sometimes extended. Confirm dates with your pharmacist.
For more information about the savings card call 1-800-842-6031 or write to: PRISTIQ Savings Card, 14001 Weston Parkway, Suite 103, Cary, NC 27513-9967

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