Do not take PRISTIQ if you are allergic to desvenlafaxine, venlafaxine, or any of the ingredients in PRISTIQ. Do not take PRISTIQ if you currently take, or have taken within the last 14 days, any medicine known as an MAOI (including intravenous methylene blue or the antibiotic linezolid). Allow 7 days after stopping PRISTIQ before starting an MAOI. Taking an MAOI with PRISTIQ can cause serious or even life-threatening side effects.

Before taking PRISTIQ, tell your healthcare professional about all prescription and over-the-counter medications and supplements you take or plan to take including: those to treat migraines or psychiatric disorders (including other antidepressants) to avoid serotonin syndrome, a potentially life-threatening condition; aspirin, NSAID pain relievers, or blood thinners because they may increase the risk of bleeding.

PRISTIQ may cause or worsen some conditions, so tell your healthcare professional about all the medical conditions you have or had including:

• High blood pressure, which should be controlled before starting PRISTIQ and monitored regularly
• Heart problems, high cholesterol or triglyceride levels, a history of stroke, kidney or liver problems, or low sodium levels in your blood
• Bleeding problems
• Depression, suicidal thoughts or behavior
• Mania, bipolar disorder, or seizures or convulsions
• Nursing, pregnancy, or plans to become pregnant

Some people are at risk for visual problems such as eye pain, changes in vision, or swelling or redness around the eye. You may want to undergo an eye examination to see if you are at risk and get preventative treatment if you are.

Discontinuation symptoms may occur when stopping or reducing PRISTIQ, so talk to your healthcare professional before stopping or changing your dose.

Until you see how PRISTIQ affects you, be careful driving a car or operating machinery. Avoid drinking alcohol while taking PRISTIQ.

In clinical studies, most common side effects with PRISTIQ 50 mg were nausea, dizziness, sweating, constipation, and decreased appetite.

INDICATION

PRISTIQ (desvenlafaxine) is a prescription medication approved for the treatment of major depressive disorder in adults.

* Terms and Conditions

By participating in the PRISTIQ Savings Card program, you acknowledge that you currently meet the eligibility criteria and will comply with the terms and conditions described below:

• As per federal and some state laws, the Card is not valid for prescriptions that are eligible to be reim bursed, in whole or in part, by Medicaid, Medicare or other federal or state healthcare programs including any state prescription drug assistance programs and the Government Health Insurance Plan available in Puerto Rico (formerly known as "La Reforma de Salud")
• The Card is not valid for prescriptions that are eligible to be reimbursed by private insurance plans or other health or pharmacy benefit programs, which reimburse you for the entire cost of your prescription drugs
• By using this Card, if your copay is $75 or less each month, you will pay $15
  • If your copay is over $75 per month, you can use this Card to save $60 each month
  • The maximum savings per month is $60, and the maximum savings per calendar year is $720
• You must deduct the value received under this program from any reimbursement request submitted to your insurance plan, either directly by you or on your behalf
• Cannot be combined with any other rebate/coupon, free trial, or similar offer for the specified prescription
• The Card will be accepted only at participating pharmacies
• This Card is not health insurance
• Offer good only in the U.S. and Puerto Rico
• The Card is limited to 1 per person during this offering period and is not transferable
• Pfizer reserves the right to rescind, revoke, or amend the program without notice
• No membership fees
• Card and Program expire 12/31/16. Program dates are sometimes extended. Confirm dates by calling 1-855-498-3563

Visit www.PRISTIQ.com for more information about PRISTIQ. For help with the PRISTIQ Savings Card, call 1-855-498-3563, or write: PRISTIQ Savings Card, 14001 Weston Parkway, Suite 103, Cary, NC 27513-9967. Be sure to include your name and mailing address.

For reimbursement when using a nonparticipating pharmacy/mail order: Pay for PRISTIQ prescription and mail copy of original pharmacy receipt (cash register receipt NOT valid) with product name, date, and amount circled to: PRISTIQ Savings Card, 14001 Weston Parkway, Suite 103, Cary, NC 27513-9967. Be sure to include a copy of the front of your Savings Card, your name, and mailing address.