Scroll for Important Safety Information and Indication

IBRANCE may cause serious side effects, including:
Low white blood cell counts (neutropenia). Low white blood cell counts are very common when taking IBRANCE and may cause serious infections that can lead to death. Your healthcare provider should check your white blood cell counts before and during treatment.

If you develop low white blood cell counts during treatment with IBRANCE, your healthcare provider may stop your treatment, decrease your dose, or may tell you to wait to begin your treatment cycle. Tell your healthcare provider right away if you have signs and symptoms of low white blood cell counts or infections such as fever and chills.


IBRANCE may cause serious or life-threatening
blood clots in the arteries of your lungs (pulmonary embolism or PE). Tell your healthcare provider right away if you experience:

  • shortness of breath
  • sudden sharp pain that may become
    worse with deep breathing
  • rapid heart rate
  • rapid breathing

Before you take IBRANCE, tell your healthcare provider if you:

  • have fever, chills, or any other signs or symptoms of infection.
  • have liver or kidney problems.
  • have any other medical conditions.
  • are pregnant or plan to become pregnant;
    IBRANCE can harm your unborn baby.
    • Females who are able to become pregnant and
      who take IBRANCE should use effective birth
      control during treatment and for at least 3 weeks
      after stopping IBRANCE.
    • Males who are taking IBRANCE with female
      partners who can become pregnant should use
      effective birth control during treatment with
      IBRANCE and for 3 months after the final dose
      of IBRANCE.
  • are breastfeeding or plan to breastfeed; it is not known if IBRANCE passes into your breast milk. You and your healthcare provider should decide if you will take IBRANCE or breastfeed. You should not do both.

Common side effects of IBRANCE include:

  • Low red blood cell counts and low platelet counts. Call your healthcare provider right away if you develop any of these symptoms during treatment:
    • dizziness
    • shortness of breath
    • weakness
    • bleeding or bruising more easily
    • nosebleeds
  • infections
  • tiredness
  • nausea
  • sore mouth
  • headache
  • diarrhea
  • constipation
  • hair thinning or hair loss
  • vomiting
  • rash
  • loss of appetite

IBRANCE may cause fertility problems in males. This may affect your ability to father a child. Talk to your healthcare provider if this is a concern for you.

These are not all of the possible side effects of IBRANCE. For more information, ask your healthcare provider. Tell your healthcare provider if you have any side effect that bothers you or does not go away.

Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. IBRANCE and other medicines may affect each other, causing side effects. Tell your healthcare provider if you start a new medicine.

Take IBRANCE exactly as your healthcare provider tells you.

Take IBRANCE capsules with food and swallow the capsules whole. Do not chew, crush, or open IBRANCE capsules before swallowing them. Do not take any IBRANCE capsules that are broken, cracked, or that look damaged. If you miss a day’s dose or vomit after taking a dose of IBRANCE, do not take an extra dose; just take your next dose at your regular time. Do not drink grapefruit juice or eat grapefruit products while taking IBRANCE. Grapefruit or grapefruit juice may increase the amount of IBRANCE in your blood.

If you take too much IBRANCE, call your healthcare provider right away or go to the nearest hospital emergency room.

Indication

IBRANCE is a prescription medicine used to treat hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) breast cancer that has spread to other parts of the body (metastatic) in combination with letrozole as the first hormonal based therapy in women who have gone through menopause.

The effectiveness of IBRANCE plus letrozole is based on a study that measured progression-free survival. There is an ongoing study to find out how IBRANCE works in combination with letrozole over a longer period of time.

It is not known if IBRANCE is safe and effective in children.

Please see Full Prescribing Information and Patient Information.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Terms & Conditions

Limits, terms, and conditions apply to Pfizer Co-Pay
One Savings Program. The offer will be accepted only at participating pharmacies. This offer is not health insurance. No membership fees apply. Please visit PfizerCoPayOne.com or see savings card for complete terms and conditions. For any questions, please call
1-855-612-1951 or visit PfizerCoPayOne.com.

Pfizer Inc, 235 East 42nd Street, New York, NY 10017.

© 2016 Pfizer Inc. All rights reserved. May 2016.