Do not take PRISTIQ if you are allergic to desvenlafaxine, venlafaxine, or any of the ingredients in PRISTIQ. Do not take PRISTIQ if you currently take, or have taken within the last 14 days, any medicine known as an MAOI (including intravenous methylene blue or the antibiotic linezolid). Allow 7 days after stopping PRISTIQ before starting an MAOI. Taking an MAOI with PRISTIQ can cause serious or even life-threatening
side effects.

Before taking PRISTIQ, tell your healthcare professional about all prescription and over-the-counter medications and supplements you take or plan to take including: those to treat migraines or psychiatric disorders (including other antidepressants) to avoid serotonin syndrome, a potentially life-threatening condition; aspirin, NSAID pain relievers, or blood thinners because they may increase the risk of bleeding.

PRISTIQ may cause or worsen some conditions, so tell your healthcare professional about all the medical conditions you have or had including:

• High blood pressure, which should be controlled before starting PRISTIQ and monitored regularly
• Heart problems, high cholesterol or triglyceride levels, a history of stroke, kidney or liver problems, or low sodium levels in your blood
• Bleeding problems
• Depression, suicidal thoughts or behavior
• Mania, bipolar disorder, or seizures or convulsions
• Nursing, pregnancy, or plans to become pregnant

Some people are at risk for visual problems such as eye pain, changes in vision, or swelling or redness around the eye. You may want to undergo an eye examination to see if you are at risk and get preventative treatment if you are.

Discontinuation symptoms may occur when stopping or reducing PRISTIQ, so talk to your healthcare professional before stopping or changing your dose.

Until you see how PRISTIQ affects you, be careful driving a car or operating machinery. Avoid drinking alcohol while taking PRISTIQ.

In clinical studies, most common side effects with PRISTIQ 50 mg were nausea, dizziness, sweating, constipation, and decreased appetite.

PRISTIQ (desvenlafaxine) is a prescription medication approved for the treatment of major depressive disorder in adults.

By participating in the PRISTIQ^®    (desvenlafaxine) $4 Co-pay Card program, you acknowledge that you currently meet the eligibility criteria and will comply with the terms and conditions described below:

• The Card is not valid for prescriptions that are eligible to be reimbursed, in whole or in part, by Medicaid, Medicare, or other federal or state healthcare programs including any state prescription drug assistance programs and the Government Health Insurance Plan available in Puerto Rico (formerly known as “La Reforma de Salud”)
• The Card is not valid for prescriptions that are eligible to be reimbursed by private insurance plans or other health or pharmacy benefit programs, which reimburse you for the entire cost of your prescription drugs
• You must be 18 or older
• Eligible patients will pay a minimum of $4 per prescription fill. By using the Card, eligible patients will receive a savings of up to $75 per fill off their co-pay or out-of-pocket costs. The Card is good for a maximum savings of $900 per year ($75 per month x 12 months). The Card limits your prescription cost to $4, subject to a maximum $75 monthly benefit. Thus,
  if your co-pay or out-of-pocket cost is more than $79, you will save $75 off of your co-pay or total
  out-of-pocket costs. [Example: If your co-pay or
  out-of-pocket costs are $100, you will pay $25
  ($100-$75=$25).] If your co-pay or out-of-pocket costs
  are no more than $79, you pay $4. For a mail-order
  3-month prescription, your total maximum savings will
  be $225 ($75x3)
• You must deduct the savings received under this program from any reimbursement request submitted to your insurance plan, either directly by you or on
  your behalf
• Cannot be combined with any other rebate/coupon, free trial, or similar offer for the specified prescription
• The Card will be accepted only at participating pharmacies
• The Card is not health insurance
• This offer is good only in the US and Puerto Rico
• Not valid where otherwise prohibited by law
• The Card is limited to 1 per person during this offering period and is not transferable
• Pfizer reserves the right to rescind, revoke, or amend the program without notice
• No membership fees
• The Card and program expire on 12/31/17

Visit www.PRISTIQ.com for more information about PRISTIQ. For help with the PRISTIQ Savings Card, call
1-855-440-6852, or write: PRISTIQ Savings Card, 2250 Perimeter Park Drive, Suite 300, Morrisville, NC 27560. Be sure to include your name and mailing address.

For reimbursement when using a nonparticipating pharmacy/mail order: Pay for PRISTIQ prescription and mail copy of original pharmacy receipt (cash register receipt NOT valid) with product name, date, and amount circled to: PRISTIQ Savings Card, 2250 Perimeter Park Drive, Suite 300, Morrisville, NC 27560. Be sure to include a copy of the front of your Savings Card, your name, and mailing address.

• According to IMS Pharmacy Benchmarks, created
  from National Prescription Audit™ (NPA), the average
  co-pay of generic antidepressants, based on Moving
  Annual Total (MAT) as of April 2016, may range
  between $3.31 and $105.34 (for branded generic
  selegiline).
• Does not imply comparable efficacy or safety.
  Products may have different indications.